Description

2-Fluoro-4-Methyl-5-Nitropyridine is a high-purity, multi-functional heterocyclic building block of significant commercial and research interest. Its core value lies in its unique molecular architecture, which combines electron-withdrawing nitro and fluorine substituents on a pyridine scaffold, making it a versatile intermediate for synthesizing complex molecules. This compound is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing new active ingredients, agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other biologically active heterocycles.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the fluorine atom can enhance biological activity and environmental stability.
• Material Science Research: Serves as a building block for creating functionalized polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: Employed as a model substrate in methodological studies for cross-coupling reactions, nucleophilic aromatic substitution (SNAr), and other transformations.
• Fine Chemical Production: An intermediate for manufacturing specialty chemicals, dyes, and complex ligands used in catalysis.

Basic Information

Product Name	2-Fluoro-4-Methyl-5-Nitropyridine
CAS No.	19346-47-5
Molecular Formula	C6H5FN2O2
Molecular Weight	156.11 g/mol
Synonyms	5-Nitro-2-fluoro-4-picoline; 2-Fluoro-4-methyl-5-nitropyridine; 4-Methyl-2-fluoro-5-nitropyridine; 5-Nitro-2-fluoro-4-methylpyridine; 2-Fluoro-5-nitro-4-picoline; 19346-47-5; 4-Picoline, 2-fluoro-5-nitro-; 2-Fluoro-4-methyl-5-nitro-pyridine
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-Methyl-5-Nitropyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent lot-to-lot quality. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.