Description

2-Fluoro-3-Nitro-4-Picoline is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound is valued for its unique reactivity profile, where the fluorine and nitro substituents on the pyridine ring enable precise chemical modifications. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Material Science Research: Serves as a building block for creating functionalized ligands, metal-organic frameworks (MOFs), and specialty polymers.
• Chemical Research & Development: Employed in method development and as a model substrate for studying nucleophilic aromatic substitution and other fluoropyridine chemistries.
• Fine Chemical Production: Acts as a versatile intermediate for manufacturing dyes, pigments, and other high-value fluorinated specialty chemicals.

Basic Information

Product Name	2-Fluoro-3-Nitro-4-Picoline
CAS No.	19346-43-1
Molecular Formula	C6H5FN2O2
Molecular Weight	156.11 g/mol
Synonyms	4-Methyl-2-fluoro-3-nitropyridine; 3-Nitro-2-fluoro-4-picoline; 2-Fluoro-3-nitro-4-methylpyridine; 4-Picoline, 2-fluoro-3-nitro-; 2-Fluoro-3-nitro-4-methylpyridine; 4-Methyl-3-nitro-2-fluoropyridine
EINECS	Contact for details

Quality Control

Our 2-Fluoro-3-Nitro-4-Picoline is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, confirming compliance with customer specifications and industry best practices.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.