Description

2,5-Dimethylbenzenesulfonyl Chloride is a versatile and highly reactive sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to act as a sulfonylation reagent, introducing the robust and modifiable 2,5-dimethylbenzenesulfonyl group into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to create sulfonamides and other functional intermediates with tailored properties.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for creating sulfonamide-based drugs with potential antibacterial, diuretic, or anti-inflammatory properties.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides, where the sulfonyl group can enhance biological activity and stability.
• Dye and Pigment Manufacturing: Acts as an intermediate in the synthesis of specialty dyes and organic pigments, contributing to color fastness and molecular structure.
• Polymer Modification: Employed to introduce sulfonyl functionalities into polymers, altering their physical properties such as solubility, thermal stability, or reactivity for advanced material science applications.
• Chemical Research & Development: A valuable tool in medicinal chemistry and process chemistry for probing structure-activity relationships and developing new synthetic methodologies.
• Ligand and Catalyst Preparation: Used to synthesize specialized ligands and organocatalysts for asymmetric synthesis and other catalytic processes.

Basic Information

Product Name	2,5-Dimethylbenzenesulfonyl Chloride
CAS No.	19040-62-1
Molecular Formula	C8H9ClO2S
Molecular Weight	204.67 g/mol
Synonyms	2,5-Dimethylbenzenesulfonyl chloride; p-Xylene-2-sulfonyl chloride; 2,5-Dimethylphenylsulfonyl chloride; 2,5-Dimethylbenzene-1-sulfonyl chloride; 1-Sulfo-2,5-dimethylbenzene chloride; 2,5-Xylenesulfonyl chloride; NSC 403119
EINECS	242-804-9

Quality Control

Our 2,5-Dimethylbenzenesulfonyl Chloride is produced under stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, identity, and impurity profiles. We are committed to meeting the exacting standards required for research and industrial-scale synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) to prevent decomposition. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or lumps
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	64 - 68 °C
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.