Description

Tetrahydrouridine (THU) is a potent and specific inhibitor of cytidine deaminase, a key enzyme in nucleoside metabolism. This compound is crucial for enhancing the stability and therapeutic efficacy of nucleoside analog drugs, particularly in oncology research. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and manufacturers in the life sciences sector for drug development, biochemical studies, and diagnostic applications.

Application

• Oncology Research: Used to potentiate the anti-cancer activity of nucleoside analogs like cytarabine (ara-C) and gemcitabine by inhibiting their deactivation.
• Biochemical Studies: Serves as a critical research tool for studying cytidine deaminase enzyme kinetics, pathways, and inhibition mechanisms.
• Drug Formulation: Incorporated into experimental therapeutic formulations to improve the pharmacokinetic profile and bioavailability of sensitive nucleoside drugs.
• Diagnostic Development: Employed in the development of diagnostic assays and kits that measure cytidine deaminase activity or related metabolic functions.
• Cell Culture & In Vitro Models: Applied in cell-based assays to modulate intracellular nucleoside pools and study cell cycle effects.

Basic Information

Product Name	Tetrahydrouridine
CAS No.	18771-50-1
Molecular Formula	C9H14N2O5
Molecular Weight	230.22 g/mol
Synonyms	THU; Tetrahydrouridine; 1,2,3,4-Tetrahydro-2,4-dioxo-1-β-D-ribofuranosyl-1,3,5-triazine; 1-(β-D-Ribofuranosyl)-1,2,3,4-tetrahydro-2,4-dioxopyrimidine; NSC-112907; 1,2,3,4-Tetrahydro-2,4-dioxo-1-(β-D-ribofuranosyl)-1,3,5-triazine; Cytidine deaminase inhibitor
EINECS	242-562-9

Quality Control

Our Tetrahydrouridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets high-purity standards suitable for research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.