Description

L-Lysine, [14C(U)]- is a carbon-14 radiolabeled form of the essential amino acid L-Lysine, uniformly labeled across the molecule. This compound is a critical tool for metabolic pathway tracing and pharmacokinetic studies, offering researchers a reliable method to track the absorption, distribution, metabolism, and excretion (ADME) of lysine and related compounds. It is indispensable for scientists in pharmaceutical development, nutritional biochemistry, and agricultural research who require precise, high-specific-activity tracers for their investigative work.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a radiotracer to investigate the ADME profile of lysine-containing drugs and peptides.
• Biochemical Pathway Analysis: Essential for tracing lysine metabolism, including its role in protein synthesis, cross-linking (via hydroxylysine in collagen), and conversion to other metabolites like acetyl-CoA.
• Nutritional Research: Employed in studies to understand lysine utilization, bioavailability, and requirements in humans and animals.
• Agricultural & Animal Feed Studies: Used to trace the metabolic fate of lysine supplements in livestock to optimize feed formulations.
• Proteomics and Protein Turnover Research: Facilitates the study of protein synthesis rates and degradation by incorporating the labeled amino acid into newly formed proteins.
• In Vitro and In Vivo Imaging Agent Development: Serves as a precursor for developing targeted imaging probes for positron emission tomography (PET) when used with carbon-11, though this specific isotope is for detailed metabolic tracing.

Basic Information

Product Name	L-Lysine, [14C(U)]-
CAS No.	18746-72-0
Molecular Formula	C614C?H14N2O2 *Note: Formula indicates uniform 14C labeling.
Molecular Weight	Contact for details (varies with specific activity)
Synonyms	(2S)-2,6-Diamino[U-14C]hexanoic acid; L-[U-14C]Lysine; [U-14C]-L-Lysine; Lysine-14C(U); (S)-2,6-Diamino[14C(U)]caproic acid; H-Lys-OH-14C(U); L-2,6-Diamino[U-14C]hexanoic acid; Uniformly Labeled Carbon-14 L-Lysine
EINECS	Contact for details

Quality Control

Every batch of L-Lysine, [14C(U)]- is manufactured and analyzed under strict quality systems to ensure high chemical, radiochemical, and enantiomeric purity. Our products undergo rigorous quality testing to ensure compliance with industry standards for radiolabeled compounds. Certificates of Analysis (COA) detailing specific activity, purity by HPLC, radiochemical purity, and enantiomeric excess are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep container sealed under an inert atmosphere in a dedicated freezer. Adhere to all local and international regulations for the storage and handling of radioactive materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Specific Activity	Contact for details (mCi/mmol)
Assay (HPLC)	≥ 98% (Chemical Purity)
Radiochemical Purity (Radio-HPLC)	≥ 97%
Enantiomeric Purity (Chiral HPLC)	≥ 99% L-Isomer
Solubility	Soluble in water, dilute acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.