Description

Tetrodotoxin Citrate is a highly specific and potent sodium channel blocker, derived from the natural neurotoxin tetrodotoxin and stabilized as a citrate salt. This compound is critical for advanced neuroscience research and pharmacological studies, providing a powerful tool for investigating neural signaling pathways and ion channel function. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and diagnostic manufacturers requiring precise neurochemical agents for high-value applications.

Application

• Neuroscience Research: As a selective sodium channel antagonist for studying action potential generation, neuronal excitability, and synaptic transmission in vitro and in vivo.
• Pharmacological Tool Compound: Used in high-throughput screening (HTS) and target validation assays to discover and develop novel analgesics and neuroprotective agents.
• Ion Channel Studies: Essential for electrophysiology experiments (e.g., patch-clamp) to characterize the function and kinetics of voltage-gated sodium channels (VGSCs).
• Toxicology & Safety Testing: Serves as a reference standard and positive control in assays designed to detect sodium channel-blocking activity in drug candidates or environmental samples.
• Diagnostic Development: Used in the development of sensitive biochemical assays and biosensors for detecting marine biotoxins.
• Biochemical Pathway Analysis: A key reagent for dissecting pain signaling pathways and mechanisms of neurotoxicity.

Basic Information

Product Name	Tetrodotoxin Citrate
CAS No.	18660-81-6
Molecular Formula	C₁₁H₁₇N₃O₈ • xC₆H₈O₇
Molecular Weight	319.27 (Tetrodotoxin base) + Citric acid moiety
Synonyms	TTX Citrate; Tetrodotoxin Citrate Salt; Anhydrotetrodotoxin 4-epitetrodotoxin Citrate; Tarichatoxin Citrate; Spheroidine Citrate; Maculotoxin Citrate; Fugu Poison Citrate; (S)-Tetrodotoxin Citrate
EINECS	Contact for details

Quality Control

Our Tetrodotoxin Citrate is produced under strict quality management systems to ensure exceptional purity and batch-to-batch consistency for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to stringent in-house specifications, and our quality protocols are designed to support compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This product is hygroscopic (moisture-sensitive) and strictly light-sensitive (protect from all light exposure). For long-term stability, store under inert atmosphere in a cool, dry place. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥ 95.0% (Tetrodotoxin base)
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm
Biological Activity	Confirmed by functional assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.