Description

1-Benzothiophene-3-Sulfonyl Chloride is a high-purity, reactive organosulfur building block essential for advanced chemical synthesis. This compound serves as a critical sulfonylation reagent, enabling the efficient introduction of the benzothiophene sulfonyl moiety into target molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of kinase inhibitors, receptor antagonists, and other small-molecule drug candidates featuring the benzothiophene scaffold.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides where the sulfonamide group enhances biological activity.
• Material Science Research: Building block for creating functional polymers, dyes, and organic electronic materials with specific optoelectronic properties.
• Chemical Biology Probes: Employed in the design of activity-based probes and covalent inhibitors for studying enzyme function and protein labeling.
• Sulfonamide Library Synthesis: A versatile reagent for parallel and combinatorial chemistry to generate diverse sulfonamide libraries for high-throughput screening.

Basic Information

Product Name	1-Benzothiophene-3-Sulfonyl Chloride
CAS No.	18494-87-6
Molecular Formula	C8H5ClO2S2
Molecular Weight	232.70 g/mol
Synonyms	Benzo[b]thiophene-3-sulfonyl chloride; 3-Benzothiophenesulfonyl chloride; 1-Thianaphthene-3-sulfonyl chloride; Benzothiophene-3-sulfonyl chloride; 3-Thianaphthenesulfonyl chloride; BTSC; 1-Benzothiophene-3-sulfonchlorid
EINECS	Contact for details

Quality Control

Our 1-Benzothiophene-3-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and reliability for your critical synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	98 - 102 °C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.