Description

1-o-Methyl-β-D-Glucuronide Methyl Ester CAS NO 18486-38-9 is a chemically modified derivative of glucuronic acid, serving as a crucial intermediate and reference standard in advanced organic synthesis and analytical chemistry. Its primary value lies in its role as a protected building block for the synthesis of complex carbohydrates, glycoconjugates, and other bioactive molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries who require high-purity intermediates for drug discovery, metabolic studies, and the development of novel glycosylation methodologies.

Application

• Pharmaceutical Intermediate: A key protected synthon for the synthesis of glycosides, prodrugs, and complex carbohydrate-based active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a reference standard and substrate in enzymatic studies, particularly those involving glucuronidases and carbohydrate metabolism pathways.
• Glycochemistry & Glycobiology: Serves as a fundamental building block for constructing oligosaccharides, glycopeptides, and other glycoconjugates for structure-activity relationship studies.
• Analytical Standard: Employed in HPLC, LC-MS, and NMR as a high-purity calibration standard for method development and quantification in complex matrices.
• Fine Chemical Synthesis: Utilized in custom synthesis and process development for creating specialty chemicals with specific stereochemical configurations.

Basic Information

Product Name	1-o-Methyl-β-D-Glucuronide Methyl Ester
CAS No.	18486-38-9
Molecular Formula	C8H14O7
Molecular Weight	222.19 g/mol
Synonyms	Methyl (methyl 4-O-methyl-β-D-glucopyranosid)uronate; Methyl 1-O-Methyl-β-D-glucopyranosiduronate; 1-O-Methyl-β-D-glucuronic acid methyl ester; Methyl β-D-glucopyranosiduronic acid, 1-methyl ester; β-D-Glucopyranosiduronic acid, methyl 1-methyl ester; 1-Methoxy-β-D-glucuronic acid methyl ester
EINECS	Contact for details

Quality Control

Our 1-o-Methyl-β-D-Glucuronide Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.