Description

Cyclopiazonic Acid is a potent mycotoxin and a specific inhibitor of the sarcoplasmic/endoplasmic reticulum Ca²⁺-ATPase (SERCA) pump. This high-purity biochemical is essential for researchers investigating calcium signaling pathways, muscle physiology, and the toxicology of fungal metabolites. It serves as a critical tool compound for pharmaceutical, biotechnology, and academic laboratories focused on cell biology, neurobiology, and toxicology research.

Application

• Biochemical Research: A key pharmacological tool for studying intracellular calcium homeostasis and signaling by specifically inhibiting SERCA pumps.
• Neuroscience Studies: Used to investigate the role of calcium dysregulation in neuronal function and neurodegenerative processes.
• Toxicology & Mycology: Serves as a reference standard for the analysis of mycotoxin contamination in food, feed, and environmental samples.
• Muscle Physiology Research: Applied in studies of skeletal and cardiac muscle contraction and relaxation mechanisms.
• Cell Biology: Utilized to induce endoplasmic reticulum stress and study the unfolded protein response (UPR) in various cell models.
• Pharmaceutical Development: Acts as a lead compound or probe in drug discovery programs targeting calcium-dependent pathways.

Basic Information

Product Name	Cyclopiazonic Acid
CAS No.	18172-33-3
Molecular Formula	C₂₀H₂₀N₂O₃
Molecular Weight	336.39 g/mol
Synonyms	CPA; α-Cyclopiazonic Acid; 3,10,13a-Trimethyl-1,2,3,4,8,9,10,11,12,13a-decahydro-6H-pyrrolo[2',1':5,6]pyrano[3,2-b]indolizine-1,4,6,12(2H,5H)-tetraone; 2,4-Dimethyl-6-(2-oxo-1-pentyl)-3,4-seco-4-oxoquinoline-3-carboxylic acid; Mycotoxin CPA
EINECS	Contact for details

Quality Control

Our Cyclopiazonic Acid is manufactured under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to rigorous quality testing protocols, and specifications can be aligned with customer requirements for specific research or development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Keep away from heat and incompatible materials. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Solubility	Soluble in DMSO, methanol; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.