Description

22-Hydroxycholesterol is a significant oxysterol metabolite of cholesterol, playing a crucial role in the regulation of bile acid synthesis and lipid metabolism. This compound is of high interest in biochemical research as a potent endogenous ligand for the liver X receptor (LXR), a key nuclear receptor involved in cholesterol homeostasis and inflammation. It is an essential reference standard and intermediate for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors, particularly those focused on metabolic disease, cardiovascular research, and drug discovery.

Application

• Biochemical Research: Used as a critical reference standard and agonist in studies of liver X receptor (LXR) signaling pathways.
• Pharmaceutical Intermediates: Serves as a key starting material or intermediate in the synthesis of novel therapeutic agents targeting cholesterol metabolism.
• Metabolic Disease Studies: Essential for in vitro and in vivo research into atherosclerosis, diabetes, and other lipid-related disorders.
• Cell Signaling & Regulation: Employed to investigate the role of oxysterols in gene expression, inflammation, and immune response.
• Diagnostic Development: Utilized in the development and calibration of assays for oxysterol quantification in biological samples.
• Academic Research: A vital tool for universities and research institutes exploring fundamental biochemistry and molecular biology.

Basic Information

Product Name	22-Hydroxycholesterol
CAS No.	17711-16-9
Molecular Formula	C27H46O2
Molecular Weight	402.66 g/mol
Synonyms	22(R)-Hydroxycholesterol; (22R)-Cholest-5-ene-3β,22-diol; 22R-Hydroxycholesterol; 3β,22-Dihydroxycholest-5-ene; 22-HC; LXR Ligand; Oxysterol 22HC
EINECS	Contact for details

Quality Control

Our 22-Hydroxycholesterol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent batch-to-batch reliability.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. The product is light-sensitive and easily oxidized. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Specific Rotation	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.