Description

2,4,5-Trifluoropyrimidine is a versatile fluorinated heterocyclic building block essential for modern synthetic chemistry. Its value lies in its ability to introduce a trifluoromethylpyrimidine-like motif, which is critical for modulating the physicochemical and biological properties of target molecules. This high-purity intermediate is primarily needed by pharmaceutical and agrochemical R&D teams for the synthesis of active ingredients, as well as by manufacturers of advanced materials and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors, antiviral agents, and other small-molecule therapeutics where the fluoropyrimidine core enhances metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where fluorine substitution improves lipophilicity and environmental persistence.
• Material Science Precursor: Serves as a building block for fluorinated liquid crystals, organic semiconductors, and polymers that require specific electronic properties and thermal stability.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex, diversely functionalized pyrimidine derivatives.
• Nucleophilic Aromatic Substitution: The fluorine atoms at the 2, 4, and 5 positions are selectively displaceable, allowing for stepwise, regioselective functionalization to create tailored chemical libraries.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research focused on exploring new fluorination methodologies and the effects of fluorine in medicinal chemistry.

Basic Information

Product Name	2,4,5-Trifluoropyrimidine
CAS No.	17573-79-4
Molecular Formula	C4HF3N2
Molecular Weight	134.06 g/mol
Synonyms	2,4,5-Trifluoropyrimidine; Pyrimidine, 2,4,5-trifluoro-; 2,4,5-Trifluoro-1,3-diazine; 2,4,5-Trifluoropyrimidine (stabilized); 2,4,5-Trifluoro-pyrimidine; NSC 405124; A1-015/40208050; LS-1963; 2,4,5-Trifluoropyrimidine, 97%
EINECS	Contact for details

Quality Control

Every batch of 2,4,5-Trifluoropyrimidine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA), including assay by GC/HPLC and impurity profile, is supplied with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile nature, store in a cool, well-ventilated place at recommended room temperature (15-25°C). Keep away from strong acids and organic solvents. For long-term storage, consider keeping under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.