Description

Cerulenin is a potent, naturally occurring fungal metabolite that acts as a specific and irreversible inhibitor of fatty acid and polyketide synthases. This unique mode of action makes it an invaluable research tool for studying lipid metabolism and biosynthetic pathways in living systems. It is primarily utilized by researchers and scientists in the fields of biochemistry, microbiology, and pharmacology for mechanistic studies and target validation.

Application

• Biochemical Research: A critical tool for inhibiting fatty acid synthase (FAS), enabling studies on lipid biosynthesis, membrane biogenesis, and energy metabolism in cells.
• Antimicrobial Studies: Used to investigate novel antibiotic targets by disrupting bacterial and fungal cell wall lipid synthesis pathways.
• Cancer Research: Employed in preclinical studies to explore the therapeutic potential of FAS inhibition on tumor cell proliferation and survival.
• Metabolic Pathway Analysis: Essential for probing and mapping polyketide and secondary metabolite synthesis in microorganisms and plants.
• Pharmacology & Drug Discovery: Serves as a reference compound for screening and developing new antimicrobial or anticancer agents targeting lipid synthesis.
• Academic & Industrial R&D: Used in university laboratories and pharmaceutical R&D departments for fundamental and applied life science research.

Basic Information

Product Name	Cerulenin
CAS No.	17397-89-6
Molecular Formula	C12H17NO3
Molecular Weight	223.27 g/mol
Synonyms	(2R,3S)-2,3-Epoxy-4-oxo-7,10-dodecadienoylamide; Antibiotic Cerulenin; NSC 166101; 2,3-Epoxy-4-oxo-7,10-dodecadienamide; L-2,3-Epoxy-4-oxo-7,10-dodecadienoylamide; (2R,3S)-2,3-Epoxy-4-oxo-7,10-dodecadienamide; Fatty Acid Synthase Inhibitor I
EINECS	Contact for details

Quality Control

Our Cerulenin is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research-grade biochemicals to guarantee reliable and reproducible experimental results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. The container should be kept in a dry, well-ventilated area. Allow the product to reach room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to pale yellow powder or crystals
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95%
Water Content	≤ 1.0%
Solubility	Soluble in DMSO, ethanol; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.