Description

2-Chloro-3-Fluoropyridine is a versatile halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it a valuable intermediate for introducing both chloro and fluoro functionalities into complex molecular architectures. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders and anti-infectives.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and metabolic stability.
• Ligand and Catalyst Preparation: Used in the synthesis of specialized ligands for transition metal catalysis and organocatalysts.
• Material Science Research: Intermediate for creating functionalized polymers, liquid crystals, and electronic materials.
• Cross-Coupling Reactions: Serves as a substrate in Suzuki, Stille, and Buchwald-Hartwig amination reactions to construct biaryl systems.
• Fluorine Chemistry Exploration: A valuable reagent for studying nucleophilic aromatic substitution and other fluorine-specific reaction pathways.

Basic Information

Product Name	2-Chloro-3-Fluoropyridine
CAS No.	17282-04-1
Molecular Formula	C5H3ClFN
Molecular Weight	131.54 g/mol
Synonyms	3-Fluoro-2-chloropyridine; 2-Chloro-3-fluoropyridine; 3-Fluoro-2-pyridinyl chloride; 2-Chloro-3-fluoro-pyridine; Pyridine, 2-chloro-3-fluoro-; 17282-04-1; 3-Fluoropyridine, 2-chloro-
EINECS	Contact for details

Quality Control

Our 2-Chloro-3-Fluoropyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing including GC, HPLC, and NMR to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles. Our quality commitment ensures material consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are properly sealed and stored upright away from heat sources and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.