Description

(-)-Normetazocine >96% n-Demethylated An Alog is a high-purity, n-demethylated analog of the benzomorphan class, characterized by its specific stereochemistry. This compound is of significant interest in advanced pharmaceutical research and development, particularly for studying opioid receptor pharmacology and structure-activity relationships. It serves as a critical reference standard and synthetic intermediate for researchers and developers in the pharmaceutical, biotechnology, and fine chemical sectors.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified reference material (CRM) for analytical method development, validation, and quality control in drug discovery and development pipelines.
• Medicinal Chemistry Research: Serves as a key intermediate or lead compound for the synthesis and study of novel benzomorphan analogs targeting central nervous system (CNS) receptors.
• Pharmacological Studies: Employed in in vitro and in vivo assays to investigate opioid receptor (e.g., μ, κ) binding affinity, selectivity, and functional activity.
• Metabolite Identification: Acts as a standard for the identification and quantification of metabolites in pharmacokinetic and ADME (Absorption, Distribution, Metabolism, Excretion) studies.
• Academic & Institutional Research: Utilized in universities and research institutes for fundamental studies in neuropharmacology and analgesic drug development.
• Fine Chemical Synthesis: A building block for the custom synthesis of specialized chemical entities for preclinical and clinical research applications.

Basic Information

Product Name	(-)-Normetazocine >96% n-Demethylated An Alog
CAS No.	16603-67-1
Molecular Formula	C₁₅H₂₁NO
Molecular Weight	231.33 g/mol
Synonyms	(-)-Normetazocine; (-)-N-Normetazocine; 1,2,3,4,5,6-Hexahydro-8-hydroxy-3,6,11-trimethyl-2,6-methano-3-benzazocine; (-)-5,9-Dimethyl-2'-hydroxy-6,7-benzomorphan; 2'-Hydroxy-5,9-dimethyl-6,7-benzomorphan; (-)-N-Desmethylmetazocine; Benzomorphan analog; n-Demethylated Metazocine analog
EINECS	Contact for details

Quality Control

Our (-)-Normetazocine >96% n-Demethylated An Alog is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity confirmation, identity verification by spectroscopic methods (IR, NMR), and residual solvent analysis to ensure it meets the stringent requirements for research applications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container sealed to protect from moisture and contamination.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	>96.0%
Related Substances (HPLC)	Individual impurity ≤1.0%; Total impurities ≤4.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.