Description

2-Bromo-3,4,5,6-Tetrafluorotoluene is a versatile fluorinated aromatic building block, valued for its unique combination of bromine and fluorine substituents which impart significant reactivity and stability. This compound is essential for introducing the tetrafluoromethylphenyl moiety into complex molecular architectures, enabling precise tuning of electronic and physical properties. It is primarily sought after by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for applications in cross-coupling reactions and as a key intermediate in the synthesis of active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the fluorine atoms contribute to improved efficacy and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials, helping to optimize dielectric anisotropy and charge transport properties.
• Polymer & Resin Modifier: Incorporated into specialty polymers to enhance chemical resistance, thermal stability, and surface properties.
• Cross-Coupling Reactions: The bromine atom acts as an excellent handle for Suzuki, Stille, and other palladium-catalyzed coupling reactions to form biaryl structures.
• Organic Synthesis & Research: A valuable reagent in academic and industrial R&D for exploring new fluorination chemistry and creating complex organic molecules.

Basic Information

Product Name	2-Bromo-3,4,5,6-Tetrafluorotoluene
CAS No.	16583-13-4
Molecular Formula	C7H1BrF4
Molecular Weight	244.98 g/mol
Synonyms	2-Bromo-α,α,α,α-tetrafluorotoluene; Benzene, 1-bromo-2,3,4,5-tetrafluoro-6-methyl-; 1-Bromo-2,3,4,5-tetrafluoro-6-methylbenzene; 2-Bromotetrafluorotoluene; α,α,α,α-Tetrafluoro-2-bromotoluene; 2-Bromo-3,4,5,6-tetrafluoromethylbenzene; Toluene, 2-bromo-3,4,5,6-tetrafluoro-
EINECS	Contact for details

Quality Control

Our 2-Bromo-3,4,5,6-Tetrafluorotoluene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurity profiles, and physical data. Our quality commitment ensures batch-to-batch consistency, meeting the stringent requirements for research and commercial synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and organic solvents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.8 g/mL
Refractive Index (n20D)	~1.45

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.