Description

Quinazoline, 7-Fluoro- (8Ci) CAS NO 16499-45-9 is a fluorinated heterocyclic compound belonging to the quinazoline class, serving as a critical building block in advanced organic synthesis. Its core value lies in its role as a versatile intermediate for constructing complex molecules with tailored biological and material properties. This high-purity intermediate is essential for research and development chemists in the pharmaceutical, agrochemical, and materials science industries seeking to incorporate the quinazoline pharmacophore or a fluorine atom into novel compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) targeting various therapeutic areas, including oncology and central nervous system (CNS) disorders.
• Agrochemical Research: Used in developing novel herbicides, fungicides, and insecticides, where the fluorine atom can enhance bioavailability and environmental stability.
• Material Science: Serves as a building block for creating specialized organic electronic materials, such as OLED (Organic Light-Emitting Diode) components or conductive polymers.
• Chemical Biology Probe Development: Utilized in constructing molecular probes for studying enzyme function and biological pathways due to the quinazoline scaffold's affinity for various protein targets.
• Academic & Contract Research: A fundamental reagent for methodological development in organic chemistry and for custom synthesis projects in contract research organizations (CROs).

Basic Information

Product Name	Quinazoline, 7-Fluoro- (8Ci)
CAS No.	16499-45-9
Molecular Formula	C8H5FN2
Molecular Weight	148.14 g/mol
Synonyms	7-Fluoroquinazoline; 7-Fluoro-1,3-diazanaphthalene; Quinazoline, 7-fluoro-; 7-Fluoro-benzo[d]pyrimidine; 7-Fluoro-1,3-benzodiazine; 7-Fluoro-1,3-diazanaphthalene; 16499-45-9 (CAS); 7-Fluorquinazolin
EINECS	Contact for details

Quality Control

Our Quinazoline, 7-Fluoro- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring traceability and consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.