Description

Hemicholinium is a potent and selective competitive inhibitor of the high-affinity choline transporter (CHT1), a key component in the synthesis of the neurotransmitter acetylcholine. This specific mechanism of action makes it an invaluable research tool for studying cholinergic neurotransmission and related neurological pathways. It is primarily utilized by researchers and scientists in the fields of neuropharmacology, biochemistry, and physiology for in vitro and ex vivo experimental models.

Application

• Neuropharmacological Research: Used to investigate the dynamics of acetylcholine synthesis, release, and reuptake in synaptic terminals.
• Biochemical Studies: Employed as a selective agent to block high-affinity choline uptake in synaptosome preparations and cell culture models.
• Physiological Research: Applied in studies exploring the role of cholinergic systems in cognitive function, memory, and neuromuscular junction activity.
• Drug Discovery: Serves as a reference compound for screening and validating new therapeutic agents targeting cholinergic deficits, such as those in Alzheimer's disease and myasthenia gravis.
• Toxicology Studies: Utilized to model cholinergic hypofunction and understand the effects of neurotoxins that impair acetylcholine synthesis.

Basic Information

Product Name	Hemicholinium
CAS No.	16478-59-4
Molecular Formula	C14H22Br2N2O2
Molecular Weight	410.15 g/mol
Synonyms	Hemicholinium-3; HC-3; Hemicholinium dibromide; 2,2'-(1,4-Dioxobutane-1,4-diyl)bis(N,N,N-trimethylethanaminium) dibromide; 2,2'-(1,4-Dioxo-1,4-butanediyl)bis[N,N,N-trimethylethanaminium] dibromide; Choline reuptake inhibitor; HCh-3
EINECS	Contact for details

Quality Control

Our Hemicholinium is produced under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.