Description

1-Propynylmagnesium Bromide is a highly reactive organometallic reagent, specifically a Grignard reagent, widely used in organic synthesis. Its core value lies in its ability to act as a powerful nucleophile for the formation of new carbon-carbon bonds, enabling the construction of complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require high-purity intermediates for fine chemical synthesis.

Application

1-Propynylmagnesium Bromide is a versatile building block in synthetic chemistry. Key applications include:

• Pharmaceutical Intermediates: Synthesis of active pharmaceutical ingredients (APIs) and complex drug candidates, particularly those containing alkyne or substituted alkene functionalities.
• Agrochemical Synthesis: Production of herbicides, fungicides, and plant growth regulators that utilize propargylic structures.
• Material Science: Serving as a precursor for polymers, liquid crystals, and organic electronic materials where the alkyne group is incorporated into the backbone.
• Cross-Coupling Reactions: Acting as a coupling partner in Negishi, Kumada, and other transition metal-catalyzed cross-coupling reactions to form complex organic molecules.
• Nucleophilic Addition: Addition to carbonyl compounds (aldehydes, ketones, esters) to produce propargylic alcohols, which are valuable synthetic intermediates.
• Fine Chemical Production: Manufacture of specialty chemicals, flavors, fragrances, and dyes requiring precise alkyne functionalization.

Basic Information

Product Name	1-Propynylmagnesium Bromide
CAS No.	16466-97-0
Molecular Formula	C₃H₃BrMg
Molecular Weight	143.26 g/mol
Synonyms	Prop-1-yn-1-ylmagnesium Bromide; Propargylmagnesium Bromide; Magnesium, bromo(1-propynyl)-; Bromo(prop-1-yn-1-yl)magnesium; 1-Propynyl Grignard Reagent; Propargyl Grignard Reagent (solution); HC≡CMgBr
EINECS	Contact for details

Quality Control

Our 1-Propynylmagnesium Bromide is manufactured under stringent quality control protocols to ensure batch-to-batch consistency and reliability for critical synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as concentration (typically supplied as a solution in THF or diethyl ether), assay, and impurity profile. Our quality system is designed to meet the exacting standards required for GMP and ISO-guided production environments.

Storage

Preserve in a tightly closed container, protected from light. Due to its properties as a highly volatile and easily oxidized organometallic compound, it must be stored under an inert atmosphere (argon or nitrogen) at recommended temperatures of 2°C to 8°C. The container should be kept in a cool, dry, well-ventilated area away from moisture, heat, and incompatible materials such as acids, water, and oxidizing agents.

Specification

Item	Specification
Appearance	Clear, colorless to light yellow solution
Concentration (in THF)	0.5 M, 1.0 M, or 2.0 M (Custom concentrations available)
Assay (Titration)	≥ 95%
Identification (IR)	Conforms to structure
Water Content (Karl Fischer)	< 100 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.