Description

Dual Specificity Protein Phosphatase 1/6 Inhibitor is a potent and selective small molecule inhibitor targeting DUSP1 and DUSP6 phosphatases, key regulators of MAP kinase signaling pathways. This compound is essential for advanced biochemical research, enabling precise modulation of cellular processes for mechanistic studies and target validation. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology, immunology, and metabolic disease research.

Application

• Biochemical Research: A critical tool for studying the role of DUSP1 and DUSP6 in MAPK pathway regulation, cell proliferation, and apoptosis.
• Drug Discovery & Target Validation: Used in high-throughput screening (HTS) and hit-to-lead optimization campaigns to develop novel therapeutics for cancer and inflammatory diseases.
• Academic Research: Facilitates fundamental research in signal transduction, cellular stress responses, and gene expression control.
• Oncology Studies: Investigates the inhibition of DUSP proteins as a potential strategy to sensitize cancer cells to chemotherapy and targeted agents.
• Immunology Research: Explores the modulation of immune cell signaling and cytokine production through phosphatase inhibition.

Basic Information

Product Name	Dual Specificity Protein Phosphatase 1/6 Inhibitor
CAS No.	15982-84-0
Molecular Formula	C₁₆H₁₄N₂O₃
Molecular Weight	282.30 g/mol
Synonyms	DUSP1/6 Inhibitor; BCI (Bisphosphorylated Compound Inhibitor); (E)-2-Benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one; NSC 95397; 2-[(E)-Benzylidene]-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one; Protein Tyrosine Phosphatase Inhibitor IV; PTP Inhibitor IV
EINECS	Contact for details

Quality Control

Our Dual Specificity Protein Phosphatase 1/6 Inhibitor is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and potency. We adhere to relevant standards for research-grade biochemicals, ensuring the material is suitable for sensitive in vitro and cell-based assays.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.