Description

Vegfr2 Kinase Inhibitor I is a potent and selective small molecule inhibitor targeting the Vascular Endothelial Growth Factor Receptor 2 (VEGFR2/KDR). This compound is a critical research tool for studying angiogenesis, tumor growth, and cardiovascular diseases in preclinical models. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in oncology and vascular biology research. The product is supplied as a high-purity biochemical for investigative use.

Application

• Biochemical Research: Used as a selective inhibitor to study VEGFR2 (KDR) signaling pathways and mechanisms of action in cell-based assays.
• Angiogenesis Studies: Essential for in vitro and in vivo research on blood vessel formation, a key process in cancer, wound healing, and ischemic diseases.
• Oncology Research: A valuable tool for investigating the role of VEGFR2 in tumor progression, metastasis, and for evaluating potential anti-cancer therapeutics.
• Cardiovascular Disease Models: Applied in research models exploring pathological angiogenesis related to atherosclerosis, retinopathy, and other vascular disorders.
• High-Throughput Screening (HTS): Serves as a reference compound or positive control in drug discovery campaigns targeting kinase activity.
• Mechanistic Pharmacology: Used to elucidate downstream effects of VEGFR2 inhibition on cell proliferation, migration, and survival.

Basic Information

Product Name	Vegfr2 Kinase Inhibitor I
CAS No.	15966-93-5
Molecular Formula	C₂₁H₁₉N₅O₄
Molecular Weight	405.41 g/mol
Synonyms	SU1498; 3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-1,3-dihydro-2H-indol-2-one; VEGFR2 Kinase Inhibitor; KDR Kinase Inhibitor I; Tyrphostin SU 1498; SU-1498; VEGF Receptor 2 Inhibitor; Angiogenesis Inhibitor SU1498
EINECS	Contact for details

Quality Control

Our Vegfr2 Kinase Inhibitor I is manufactured under strict quality systems to ensure batch-to-batch consistency for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and spectral confirmation (NMR, MS) for structural identity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay results, and storage recommendations.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive). For long-term storage, keep under an inert atmosphere. Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.