Description

Ryanodine is a potent, naturally occurring alkaloid that acts as a highly specific modulator of intracellular calcium release channels, known as ryanodine receptors (RyRs). This compound is an indispensable pharmacological tool for researchers investigating calcium signaling pathways, muscle contraction, and neuronal excitability. It is primarily utilized in life science research, pharmaceutical development, and biochemical studies focused on cardiac and skeletal muscle function, as well as neurological disorders.

Application

• Biomedical Research: A critical tool for studying the structure and function of ryanodine receptors (RyR1, RyR2, RyR3) in calcium-induced calcium release (CICR).
• Cardiovascular Pharmacology: Used to investigate cardiac muscle contraction, arrhythmogenesis, and the development of therapies for conditions like heart failure and catecholaminergic polymorphic ventricular tachycardia (CPVT).
• Neurobiology: Employed in research on neuronal calcium signaling, synaptic plasticity, and the role of RyRs in neurodegenerative diseases.
• Skeletal Muscle Physiology: Essential for probing excitation-contraction coupling, malignant hyperthermia, and muscle fatigue.
• Pharmaceutical Screening: Serves as a reference compound and probe in high-throughput assays to discover novel modulators of RyR channels for therapeutic intervention.
• Toxicology Studies: Used to examine the mechanisms of action of certain plant-derived toxins and environmental agents that affect intracellular calcium homeostasis.

Basic Information

Product Name	Ryanodine
CAS No.	15662-33-6
Molecular Formula	C₂₅H₃₅NO₉
Molecular Weight	493.55 g/mol
Synonyms	Ryanodine; Ryanodin; (1S,2R,3S,4S,6R,7S,8S,9R)-6-(2-Carboxy-2-methylpropyl)-4,6,7,9-tetrahydro-1,2,3,4,7,8,9,10-octahydro-2,3,7,8,10-pentahydroxy-1-methyl-5H-1,6-epoxybenzo[a]cyclohepten-5-one; Ryania speciosa alkaloid; NSC 526224; UNII-15662MOW0N
EINECS	239-722-7

Quality Control

Our Ryanodine is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, related substances, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to minimize oxidation. The product is light-sensitive and easily oxidized. Keep the container sealed in a dry, cool, and well-ventilated place. For long-term storage, consider storing at -20°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Solubility	Soluble in DMSO, ethanol; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.