Description

3-Fluoro-1H-Pyrazole CAS NO 14521-81-4 is a versatile fluorinated heterocyclic building block essential for advanced organic synthesis. Its unique structure, featuring a fluorine atom on the pyrazole ring, makes it a critical intermediate for introducing fluorine into target molecules, thereby modulating their physicochemical and biological properties. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel drug candidates, particularly in kinase inhibitor and anti-inflammatory agent discovery.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where the fluorine atom enhances bioactivity and environmental stability.
• Material Science Research: Serves as a building block for functionalized polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Employed as a probe or labeling agent to study enzyme mechanisms and protein interactions.
• Catalyst Ligand Precursor: Utilized in the synthesis of specialized N-heterocyclic ligands for transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom fluorination projects and scale-up production under cGMP conditions.

Basic Information

Item	Details
Product Name	3-Fluoro-1H-Pyrazole
CAS No.	14521-81-4
Molecular Formula	C3H3FN2
Molecular Weight	86.07 g/mol
Synonyms	3-Fluoropyrazole; 3-Fluoro-1H-pyrazole; 1H-Pyrazole, 3-fluoro-; 3-Fluoropyrazole (principal synonym); Fluoropyrazole; 3-F-Pyrazole; 3-Fluoro-1H-1,2-diazole
EINECS	Contact for details

Quality Control

Every batch of 3-Fluoro-1H-Pyrazole is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity requirements for research and development. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting purity, identity, and impurity profiles as determined by validated methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.