Description

Tin Protoporphyrin IX Dichloride is a synthetic metalloporphyrin complex where tin is coordinated within the porphyrin macrocycle. This compound serves as a potent and selective competitive inhibitor of heme oxygenase, a critical enzyme in the heme degradation pathway. It is primarily utilized in biochemical and pharmacological research to study oxidative stress, cellular metabolism, and the therapeutic modulation of bilirubin production. Researchers in pharmaceutical development, academic institutions, and contract research organizations (CROs) rely on this high-purity chemical for its consistent inhibitory activity.

Application

• Heme Oxygenase (HO) Inhibition Studies: A standard research tool for investigating the physiological and pathological roles of heme oxygenase isoforms (HO-1, HO-2) in vitro and in vivo.
• Bilirubin Production Research: Used to modulate bilirubin levels in experimental models to study jaundice, kernicterus, and related neurological conditions.
• Oxidative Stress & Cytoprotection Assays: Employed to probe the cytoprotective mechanisms mediated by HO-1 expression in response to oxidative injury.
• Pharmacological Probe Development: Serves as a lead compound or reference standard in the development of novel therapeutic agents targeting the heme degradation pathway.
• Biochemical Reagent: Used as a specialized reagent in enzymatic assays and metabolic pathway analysis within life science research.

Basic Information

Product Name	Tin Protoporphyrin IX Dichloride
CAS No.	14325-05-4
Molecular Formula	C₃₄H₃₂Cl₂N₄O₄Sn
Molecular Weight	726.04 g/mol
Synonyms	Tin(IV) Protoporphyrin IX Dichloride; SnPP; SnPP-IX; Stannous Protoporphyrin Dichloride; Tin Protoporphyrin; HO Inhibitor SnPP; Protoporphyrin IX Tin(IV) Dichloride; 7,12-Bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(2-)-κN21,κN22,κN23,κN24]tin(IV) dichloride
EINECS	Contact for details

Quality Control

Our Tin Protoporphyrin IX Dichloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, identity confirmation by IR and mass spectrometry, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports reproducible and reliable experimental outcomes for the global scientific community.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive (store away from light). For long-term stability, consider storage under inert atmosphere at -20°C. Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Dark purple to brownish powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 95%
Loss on Drying	≤ 2.0 %
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.