Description

Oligomycin A is a potent, macrocyclic polyketide antibiotic complex member, widely recognized for its specific inhibition of mitochondrial ATP synthase (F0F1 ATPase). This high-purity biochemical tool is essential for researchers investigating cellular bioenergetics, oxidative phosphorylation, and mitochondrial function. It is a critical reagent for the life sciences, biotechnology, and pharmaceutical R&D sectors, enabling precise mechanistic studies in cell biology and metabolic research.

Application

• Mitochondrial Research: A primary tool for studying oxidative phosphorylation, ATP production, and mitochondrial membrane potential by selectively inhibiting the F0 subunit of ATP synthase.
• Cell Biology & Physiology: Used to induce metabolic stress, investigate apoptosis pathways linked to energy depletion, and study the role of mitochondria in various cellular processes.
• Cancer Research: Employed to explore the Warburg effect and target cancer cell metabolism, as many tumor cells exhibit altered mitochondrial function and reliance on glycolysis.
• Neurodegenerative Disease Models: Applied in research models for diseases like Parkinson's and Alzheimer's to understand mitochondrial dysfunction and neuronal cell death.
• Cardiovascular Research: Utilized to study ischemia-reperfusion injury and myocardial protection, where mitochondrial ATP production is a key factor.
• Biochemical Assay Development: Serves as a standard inhibitor in enzymatic assays and high-throughput screening platforms designed to discover novel modulators of mitochondrial function.
• Antibiotic Mode-of-Action Studies: Used as a reference compound in microbiological research to understand the action of ionophore and ATPase-inhibiting antibiotics.

Basic Information

Product Name	Oligomycin A
CAS No.	14104-19-9
Molecular Formula	C45H74O11
Molecular Weight	791.1 g/mol
Synonyms	Oligomycin A; Oligomycin; NSC 102816; Antibiotic 17795-A; 17795-A; Oligomycin (complex); Oligomycin A from *Streptomyces diastatochromogenes*; Oligomycin A (Antibiotic from *Streptomyces*); (1R,3S,4S,6R,8R,11S,12S,13R,14S,15S,17R,19S,20R,23S,24R,26S,27R,30S)-26-[(2S,3S,4S,5S)-3,4-Dihydroxy-2,5-dimethyloxolan-2-yl]-19-ethyl-4,6,8,11,12,13,14,15,17,20,23,24,26,27-tetradecahydro-3,7,18,22,25-pentaoxa-28-azaoctacyclo[23.8.0.01,27.03,23.04,21.06,20.011,15.012,17]tritriacontane-10,16,21,29-tetrone
EINECS	Contact for details

Quality Control

Our Oligomycin A is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and structural confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided, confirming identity, purity, and other critical parameters. We support compliance with relevant quality frameworks for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, ethanol, methanol; insoluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.