Description

3-(Difluoromethoxy)Benzenesulphonyl Chloride is a specialized organosulfur compound primarily used as a key synthetic intermediate in advanced organic chemistry. Its core value lies in its reactive sulphonyl chloride group, which enables the efficient introduction of the 3-(difluoromethoxy)phenylsulfonyl moiety into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of active ingredients and fine chemicals requiring this specific functionalized aromatic scaffold.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), especially in drug discovery programs targeting novel therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the difluoromethoxy and sulphonamide functionalities are required for bioactivity.
• Material Science Research: Serves as a monomer or precursor for developing specialized polymers and advanced materials with specific surface properties.
• Chemical Derivatization: Employed in organic synthesis to create sulfonamides, sulfonate esters, and other sulfonyl-based derivatives for research and scale-up processes.
• Ligand and Catalyst Development: Useful in the preparation of complex ligands and organocatalysts for asymmetric synthesis and other catalytic applications.

Basic Information

Product Name	3-(Difluoromethoxy)Benzenesulphonyl Chloride
CAS No.	13656-52-5
Molecular Formula	C7H5ClF2O3S
Molecular Weight	242.63 g/mol
Synonyms	3-(Difluoromethoxy)benzenesulfonyl chloride; 1-(Difluoromethoxy)-3-sulfonylchloridobenzene; m-(Difluoromethoxy)benzenesulfonyl chloride; Benzenesulfonyl chloride, 3-(difluoromethoxy)-; α,α-Difluoro-m-cresylsulfonyl chloride; 3-Difluoromethoxy phenylsulfonyl chloride
EINECS	Contact for details

Quality Control

Our 3-(Difluoromethoxy)Benzenesulphonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for demanding synthetic applications. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR to verify identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment, ensuring full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and reacts with strong bases; ensure the container is sealed under an inert atmosphere after opening to maintain stability and prevent hydrolysis. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.