Description

Calpain Inhibitor I is a potent, cell-permeable inhibitor of the calcium-dependent cysteine proteases calpain I and II. This compound is a critical research tool for studying the role of calpains in cellular processes such as apoptosis, signal transduction, and neurodegeneration. It is essential for researchers in pharmaceutical development, neuroscience, and cell biology who require high-purity biochemical reagents to ensure reliable and reproducible experimental results.

Application

• Biomedical Research: Fundamental tool for investigating calpain-mediated pathways in cellular models of disease.
• Neurodegenerative Disease Studies: Used to inhibit calpain activity in research related to Alzheimer's disease, Parkinson's disease, and traumatic brain injury.
• Cardiovascular Research: Applied in studies of myocardial ischemia-reperfusion injury and other calpain-involved cardiac conditions.
• Muscular Dystrophy Research: Employed to explore the role of calpain in muscle protein degradation and pathology.
• Apoptosis & Cell Death Mechanisms: Key reagent for dissecting the contribution of calpains to programmed cell death.
• Pharmaceutical Screening: Serves as a reference compound in high-throughput assays for discovering novel calpain inhibitors.

Basic Information

Product Name	Calpain Inhibitor I
CAS No.	13632-32-1
Molecular Formula	C₁₅H₂₆N₄O₄
Molecular Weight	326.39 g/mol
Synonyms	Ac-Leu-Leu-Nle-CHO; ALLN; N-Acetyl-Leu-Leu-Norleucinal; Calpain Inhibitor I, ALLN; MG-101; N-Acetyl-Leu-Leu-Nle-al; Calpeptin analog; Protease Inhibitor ALLN
EINECS	Contact for details

Quality Control

Our Calpain Inhibitor I is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and spectroscopic identification (NMR, MS), to ensure it meets the high standards required for critical life science research. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and potency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.