Description

γ-Amanitin is a highly potent bicyclic octapeptide and a principal toxic component of the *Amanita phalloides* (death cap) mushroom. This compound is of critical importance in biochemical research as a selective and irreversible inhibitor of RNA polymerase II, effectively halting mRNA synthesis. It is an essential tool for researchers in molecular biology, toxicology, and pharmacology studying transcription mechanisms, apoptosis, and the development of targeted therapies.

Application

• Biochemical Research: Used as a specific inhibitor to study eukaryotic transcription mechanisms and RNA polymerase II function.
• Toxicology Studies: Employed in research to understand the mechanisms of amatoxin poisoning and to develop potential antidotes.
• Apoptosis Research: A key reagent for inducing and studying programmed cell death pathways in various cell lines.
• Pharmaceutical Development: Serves as a reference standard in the development of diagnostic assays and in the search for novel therapeutic agents.
• Academic & Institutional Labs: Essential for fundamental research in universities and government research institutions.

Basic Information

Product Name	γ-Amanitin
CAS No.	13567-11-8
Molecular Formula	C39H54N10O14S
Molecular Weight	918.97 g/mol
Synonyms	γ-Amanitin; γ-Amantin; Amatoxin; Amaninamide; NSC 177337; L-Asparaginamide, L-tryptophyl-L-cysteinyl-glycyl-L-cysteinyl-L-2,3-dihydroxy-γ-oxo-N-methyl-L-norvalyl-4-hydroxy-L-prolyl-L-isoleucyl-6-hydroxy-2-(2-methyl-1-oxobutyl)-1,2,3,4-tetrahydro-8-quinolinyl-, cyclic (4→8)-peptide; Death Cap Toxin
EINECS	Contact for details

Quality Control

Our γ-Amanitin is produced and handled under strict quality protocols to ensure the highest standards of purity and consistency for research applications. Each batch is rigorously analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided to guarantee product integrity and support your research reproducibility.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive) and strictly light-sensitive (protect from all light exposure). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in methanol, DMSO; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.