Description

Benzene, 1-Cyclohexyl-2-(Trifluoromethyl)- is a specialized fluorinated aromatic compound with the CAS registry number 13376-27-7. This chemical is valued for its unique structural features, combining a benzene core with a cyclohexyl group and a trifluoromethyl substituent, which imparts distinct electronic and steric properties critical for advanced synthesis. It serves as a high-value building block or intermediate in research and industrial chemistry, particularly where the introduction of fluorine atoms is required to modulate the biological activity, stability, or lipophilicity of target molecules. Key industries that utilize this compound include pharmaceutical development, agrochemical research, and advanced material science.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of novel active pharmaceutical ingredients (APIs), especially for candidates requiring fluorinated motifs to enhance metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and pesticides, where the trifluoromethyl group can significantly improve efficacy and environmental profile.
• Liquid Crystal & OLED Material Research: Acts as a precursor or dopant in the development of fluorinated organic electronic materials for displays and lighting applications.
• Specialty Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, altering surface properties, chemical resistance, and thermal stability.
• Catalyst Ligand Development: Provides a structurally rigid and electron-deficient framework for designing novel ligands in transition metal catalysis.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions, nucleophilic substitutions, and other transformations to construct complex fluorinated molecules for various R&D programs.

Basic Information

Product Name	Benzene, 1-Cyclohexyl-2-(Trifluoromethyl)-
CAS No.	13376-27-7
Molecular Formula	C13H15F3
Molecular Weight	228.26 g/mol
Synonyms	1-Cyclohexyl-2-(trifluoromethyl)benzene; (2-Trifluoromethylphenyl)cyclohexane; 2-Cyclohexylbenzotrifluoride; alpha,alpha,α-Trifluoro-2-cyclohexyltoluene; 2-(Trifluoromethyl)cyclohexylbenzene; Benzene, cyclohexyl(trifluoromethyl)-; 1-Cyclohexyl-2-trifluoromethyl-benzene
EINECS	Contact for details

Quality Control

Our production of Benzene, 1-Cyclohexyl-2-(Trifluoromethyl)- adheres to a stringent quality management system. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency meet the high standards required for research and industrial use. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, impurity profile, and physical characteristics. Our quality commitment ensures reliable supply and batch-to-batch reproducibility for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. Due to its organic solvent nature, ensure containers are kept upright and sealed when not in use to prevent evaporation and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%
Density (at 20°C)	~1.1 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.