Description

L-Buthionine is a high-purity, non-proteinogenic amino acid derivative specifically designed for advanced biochemical and pharmaceutical research and manufacturing. Its core value lies in its role as a potent and selective inhibitor of γ-glutamylcysteine synthetase, a key enzyme in glutathione biosynthesis, making it a critical tool for modulating cellular redox states. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors who require reliable, high-quality intermediates for drug development, metabolic studies, and the production of targeted therapeutics.

Application

• Pharmaceutical Intermediate: Key starting material or building block in the synthesis of novel drug candidates targeting oxidative stress-related diseases.
• Biochemical Research: Used extensively in laboratory studies to deplete intracellular glutathione levels, enabling research into apoptosis, cancer cell sensitivity, and neurodegenerative disorders.
• Enzyme Inhibition Studies: Serves as a specific inhibitor for γ-glutamylcysteine synthetase in enzymatic assays and metabolic pathway analysis.
• Cell Culture & In Vitro Models: Applied in cell-based assays to study the effects of redox imbalance on cell viability, signaling, and response to chemotherapeutic agents.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for method development, validation, and quality control testing.
• Preclinical Development: Employed in animal model studies to investigate the therapeutic potential of glutathione modulation in various disease states.

Basic Information

Product Name	L-Buthionine
CAS No.	13073-21-7
Molecular Formula	C8H17NO4S
Molecular Weight	223.29 g/mol
Synonyms	L-Buthionine; (2S)-2-Amino-4-(butylsulfanyl)butanoic acid; L-Buthionine (free base); Buthionine; NSC 326231; BSO; L-BSO; L-Buthionine sulfoximine precursor; γ-Glutamylcysteine synthetase inhibitor
EINECS	Contact for details

Quality Control

Our L-Buthionine CAS NO 13073-21-7 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and cGMP-grade material requirements where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Optical Rotation	[α]20/D: Specific range available on COA
Chiral Purity (HPLC)	≥99.0% (L-Isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.