Description

Radicicol is a potent, naturally occurring macrocyclic antifungal antibiotic and a well-characterized Hsp90 inhibitor. This compound is a critical research tool for studying cellular stress response pathways, protein folding, and chaperone-mediated processes. It is essential for researchers and developers in pharmaceutical discovery, oncology research, and molecular biology, where precise modulation of Hsp90 client proteins is required.

Application

• Biomedical Research: As a selective Hsp90 inhibitor to study cancer biology, neurodegenerative diseases, and protein homeostasis.
• Antifungal Studies: Investigation of novel antifungal mechanisms and development of new therapeutic agents.
• Signal Transduction Research: Tool compound for dissecting kinase-dependent signaling pathways affected by Hsp90 inhibition.
• Drug Discovery: A reference standard and lead compound in the development of novel Hsp90-targeted oncology therapeutics.
• Cell Biology: Used to induce heat shock response and study chaperone function in various cell lines.
• Biochemical Assays: Critical reagent in high-throughput screening and in vitro binding assays targeting the Hsp90 complex.

Basic Information

Product Name	Radicicol
CAS No.	12772-57-5
Molecular Formula	C18H17ClO6
Molecular Weight	364.78 g/mol
Synonyms	Monorden; Antibiotic B 5354a; NSC 332598; (+)-Radicicol; NSC-332598; 1H-2-Benzopyran-7-acetic acid, 3-chloro-4,6-dihydroxy-8-methyl-6-(2-methyl-1-oxo-3-buten-1-yl)-, γ-lactone, (6R-cis)-; 3-Chloro-4,6-dihydroxy-8-methyl-6-(2-methyl-1-oxo-3-buten-1-yl)-1H-2-benzopyran-7-acetic acid γ-lactone
EINECS	Contact for details

Quality Control

Our Radicicol is produced and tested under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and potency. We ensure compliance with relevant standards for research-grade biochemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. The product is light-sensitive and easily oxidized; prolonged exposure to air, light, or elevated temperatures should be avoided. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.