Description

Tunicamycin is a potent nucleoside antibiotic complex that acts as a highly specific inhibitor of N-linked glycosylation in eukaryotic cells. This mechanism makes it an indispensable research tool for studying protein processing, secretion, and the unfolded protein response (UPR) in cell biology and biochemistry. It is primarily utilized by researchers in pharmaceutical development, academic institutions, and biotechnology companies investigating endoplasmic reticulum (ER) stress, glycoprotein function, and cancer biology.

Application

• Biomedical Research: A critical reagent for inducing ER stress and studying the unfolded protein response (UPR) in cell culture models.
• Glycobiology Studies: Used to inhibit the synthesis of N-linked glycoproteins, allowing researchers to analyze the role of glycosylation in protein folding, stability, and function.
• Cancer Research: Employed to investigate pathways of apoptosis and autophagy in cancer cells, particularly those reliant on proper protein glycosylation for survival.
• Virology: Applied in studies to understand how viral protein glycosylation affects infectivity and immune evasion.
• Drug Discovery: Serves as a reference compound and a tool for validating targets involved in glycosylation pathways for therapeutic intervention.
• Antibiotic Mechanism Studies: Used as a model compound to explore the biological effects and resistance mechanisms of nucleoside antibiotics.

Basic Information

Product Name	Tunicamycin
CAS No.	11089-65-9
Molecular Formula	C39H64N4O16 (for Tunicamycin V)
Molecular Weight	844.94 g/mol (for Tunicamycin V)
Synonyms	Tunicamycin complex; Antibiotic 24010; Tunicamycin A1; Tunicamycin A2; Tunicamycin B; Tunicamycin C; Tunicamycin D; Tunicamycin V; Streptomyces lysosuperificus antibiotic; N-Acetylglucosaminyltransferase inhibitor
EINECS	Contact for details

Quality Control

Our Tunicamycin is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for critical research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, composition, and biological activity. We ensure compliance with relevant standards for research-grade biochemicals, supporting the integrity of your scientific work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to standard
Purity (HPLC)	≥ 95% (Tunicamycin complex)
Biological Activity	≥ 95% (vs. reference standard)
Water Content (KF)	≤ 5.0 %
Solubility	Soluble in DMSO, Methanol, Ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.