Description

Palytoxin is a highly potent marine-derived polyether toxin originally isolated from soft corals of the genus *Palythoa*. As one of the most toxic non-protein substances known, it serves as a critical reference standard for neuropharmacological research and toxin detection assay development. Palytoxin CAS NO 11077-03-5 is essential for academic laboratories, biopharmaceutical R&D centers, and regulatory testing facilities requiring ultra-high-purity analytical standards. Its unparalleled biological activity makes it indispensable in studies of Na⁺/K⁺-ATPase inhibition, ion channel modulation, and cytotoxic mechanism validation.

Application

• Primary reference standard for LC-MS/MS and ELISA-based palytoxin detection in seafood safety monitoring (e.g., shellfish, coral reef fish)
• Pharmacological tool compound for investigating Na⁺/K⁺-ATPase structure-function relationships and allosteric regulation
• Calibration material for certified reference laboratories accredited to ISO/IEC 17025 for marine biotoxin analysis
• Positive control in high-content screening assays for cytotoxicity and membrane integrity disruption
• Research reagent in marine toxin biosynthesis and metabolic pathway studies
• Development and validation of rapid lateral flow immunoassays for field-deployable biotoxin detection
• Training standard for forensic toxicology and food safety emergency response teams

Basic Information

Product Name	Palytoxin
CAS No.	11077-03-5
Molecular Formula	C129H223N3O54
Molecular Weight	2680.15 g/mol
Synonyms	Palytoxin; PTX; Palytoxin A; Palytoxin B; Dehydroxypalytoxin; 42-Hydroxypalytoxin; 19-O-Methylpalytoxin; Palytoxin carboxylic acid; Ovatoxin-a (structural analog); Ciguatoxin-like toxin; Marine polyether toxin #1
EINECS	234-152-5

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. Each batch is verified for identity (HPLC retention time match + high-resolution mass spectrometry), purity (≥98.5% by HPLC-UV), and absence of microbial contamination. Testing adheres to ICH Q5A (R2) guidelines for biological impurities and follows ISO/IEC 17025-accredited methodologies where applicable. All lots meet stringent specifications for residual solvents and heavy metals per USP <232>/<233>.

Storage

Preserve in a tightly closed container, protected from light. Store at –20 °C under inert atmosphere (argon or nitrogen) to prevent degradation. Due to its hygroscopic nature, maintain relative humidity below 30% and minimize exposure to ambient air during handling. Avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC-MS)	Retention time and mass spectrum match reference standard
Assay (HPLC-UV)	≥98.5%
Related Substances (HPLC)	Single impurity ≤0.5%; Total impurities ≤1.5%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Meets ICH Q3C limits
Heavy Metals (USP <231>)	≤10 ppm
Microbial Limits (USP <61>)	Aerobic plate count ≤100 CFU/g; Absence of *E. coli*, *Salmonella*, and *S. aureus*

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.