Description

Coformycin CAS NO 11033-22-0 is a potent nucleoside analog and a transition-state analog inhibitor of adenosine deaminase (ADA). This compound is of significant value in biochemical and pharmaceutical research due to its ability to irreversibly inhibit ADA, a key enzyme in purine metabolism. It is primarily utilized by researchers in enzymology, immunology, and oncology for studying adenosine-mediated pathways and developing therapeutic strategies.

Application

• Biochemical Research: As a powerful tool for studying adenosine deaminase enzyme kinetics, mechanism, and regulation in vitro.
• Immunology Studies: Used to investigate the role of adenosine signaling in immune cell function and inflammation.
• Oncology Research: Employed in cancer research to explore the effects of modulating adenosine levels on tumor growth and the tumor microenvironment.
• Enzyme Inhibition Assays: Serves as a reference standard and positive control in high-throughput screening for ADA inhibitors.
• Metabolic Pathway Analysis: Aids in mapping purine salvage pathways and understanding disorders related to ADA dysfunction.
• Pharmaceutical Development: Used as a lead compound or reference molecule in the discovery and development of novel ADA-targeting therapeutics.

Basic Information

Product Name	Coformycin
CAS No.	11033-22-0
Molecular Formula	C₁₁H₁₄N₄O₄
Molecular Weight	266.25 g/mol
Synonyms	Coformycin; 3-β-D-Ribofuranosyl-6,7,8-trihydroimidazo[4,5-d][1,3]diazepin-8-ol; NSC 308847; Antibiotic FR 900490; FR-900490; (8R)-3-(β-D-Ribofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol
EINECS	Contact for details

Quality Control

Our Coformycin is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including identification by spectroscopic methods and purity assessment by HPLC. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.