Description

Tyrphostin A9 is a potent and selective inhibitor of platelet-derived growth factor receptor (PDGFR) tyrosine kinase. This small molecule compound is a critical research tool for studying signal transduction pathways, cellular proliferation, and angiogenesis. It is primarily utilized by researchers and scientists in the fields of oncology, cardiovascular disease, and cell biology for biochemical and pharmacological studies.

Application

• Biochemical Research: Used as a selective PDGFR inhibitor to study tyrosine kinase signaling cascades and their role in cell growth and differentiation.
• Oncology Research: Investigated for its potential to inhibit tumor growth and angiogenesis driven by PDGFR pathways in various cancer models.
• Cardiovascular Research: Applied in studies exploring the role of PDGFR in atherosclerosis, vascular remodeling, and restenosis.
• Cell Culture Studies: Employed to modulate PDGFR activity in vitro to understand its effects on fibroblast proliferation, migration, and wound healing processes.
• Pharmacology: Serves as a reference standard and lead compound in the development of novel tyrosine kinase inhibitors for therapeutic applications.

Basic Information

Product Name	Tyrphostin A9
CAS No.	10537-47-0
Molecular Formula	C16H12N2O3
Molecular Weight	280.28 g/mol
Synonyms	AG 17; Tyrphostin AG 17; 2,3,4,5-Tetrahydroxyphenyl 2-Propenyl Ketone; 3,4-Dihydroxy-2-propenylidene-3,4,5-trihydroxybenzophenone; (E)-1-(2,3,4-Trihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one; PDGFR Tyrosine Kinase Inhibitor A9
EINECS	Contact for details

Quality Control

Our Tyrphostin A9 is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals to guarantee reliable and reproducible performance in your experiments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	Yellow to brown powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.