Description

Histidine, L-, [Carboxyl-14C] CAS NO 10413-69-1 is a carbon-14 radiolabeled derivative of the essential amino acid L-Histidine, specifically labeled at the carboxyl carbon. This compound is a critical tool for metabolic and pharmacokinetic studies, enabling precise tracking of histidine and histidine-containing compounds in biological systems. It is primarily utilized by researchers and scientists in the pharmaceutical, biotechnology, and agrochemical industries for advanced tracer studies, drug metabolism research, and biochemical pathway analysis.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Tracing the absorption, distribution, metabolism, and excretion (ADME) of new drug candidates containing histidine residues.
• Biochemical Pathway Analysis: Investigating histidine metabolism, including its role in protein synthesis, histamine production, and other enzymatic pathways.
• Protein Turnover and Synthesis Research: Studying the incorporation of histidine into proteins to measure synthesis and degradation rates in cell culture or animal models.
• Agricultural Chemical Research: Tracer studies for understanding the metabolism and environmental fate of histidine-based agrochemicals.
• Nutritional Science: Research into histidine requirements, utilization, and its role as an essential amino acid in various organisms.
• Diagnostic Agent Development: Potential use in the research and development of novel diagnostic imaging agents.

Basic Information

Item	Detail
Product Name	Histidine, L-, [Carboxyl-14C]
CAS No.	10413-69-1
Molecular Formula	C6H914CN3O2
Molecular Weight	Contact for details
Synonyms	L-Histidine (carboxyl-14C); (S)-2-Amino-3-(1H-imidazol-4-yl)[1-14C]propanoic Acid; Histidine-1-14C; [14C]-L-Histidine; L-Histidine-1-14C; (S)-Histidine (carboxyl-14C); 14C-L-Histidine
EINECS	Contact for details

Quality Control

Every batch of Histidine, L-, [Carboxyl-14C] is produced and analyzed under strict quality systems to ensure the highest standards of radiochemical purity, chemical purity, and specific activity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing specific activity, purity by HPLC, radiochemical purity, and solvent content are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under appropriate conditions to minimize exposure to atmospheric moisture. Follow all applicable laboratory safety and radiation safety protocols for handling and disposal.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Chemical Purity (HPLC)	≥ 98%
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Solvent (Residual)	To be specified on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.