Description

2-Methoxybenzenesulfonyl Chloride is a versatile and reactive organosulfur compound, serving as a key building block in advanced organic synthesis. Its primary value lies in its sulfonyl chloride functional group, which readily undergoes nucleophilic substitution to form sulfonamides and sulfonate esters, enabling the construction of complex molecular architectures. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of sulfonamide-based drugs, including diuretics, antibacterial agents, and protease inhibitors.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators that require a sulfonyl moiety for biological activity.
• Dye and Pigment Manufacturing: Acts as a reactant in the creation of sulfonated dyes and colorants, enhancing solubility and fiber affinity.
• Polymer Chemistry: Employed as a modifying agent or cross-linking monomer to introduce sulfonate groups into polymers, altering their physical properties.
• Chemical Research & Development: A valuable reagent for medicinal chemistry and process development for creating novel sulfonyl-containing compounds.
• Ligand and Catalyst Preparation: Useful in synthesizing specialized ligands for metal complexes used in catalytic processes.

Basic Information

Product Name	2-Methoxybenzenesulfonyl Chloride
CAS No.	10130-87-7
Molecular Formula	C7H7ClO3S
Molecular Weight	206.65 g/mol
Synonyms	o-Anisolesulfonyl Chloride; 2-Methoxybenzenesulfonyl Chloride; o-Methoxybenzenesulfonyl Chloride; 1-Methoxy-2-sulfonylchloridobenzene; 2-Methoxyphenylsulfonyl Chloride; AS-101; Benzenesulfonyl chloride, 2-methoxy-
EINECS	233-357-5

Quality Control

Our 2-Methoxybenzenesulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade intermediates and research-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	40°C - 44°C
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.