Description

Nicotinamide, [Carbonyl-14C] is a carbon-14 labeled isotopologue of the essential vitamin B3, nicotinamide. This radiolabeled compound is a critical tool for tracing metabolic pathways, enabling precise pharmacokinetic and ADME (Absorption, Distribution, Metabolism, Excretion) studies in pharmaceutical and biochemical research. It is indispensable for researchers and scientists in the fields of drug discovery, metabolic research, and nutritional science who require high-specific-activity tracers to elucidate biological mechanisms.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a radiotracer to study the absorption, distribution, metabolism, and excretion of nicotinamide and related drug candidates.
• Biochemical Pathway Analysis: Essential for tracing the incorporation of nicotinamide into key coenzymes NAD(H) and NADP(H) and mapping related metabolic fluxes.
• Nutritional Research: Employed to investigate the bioavailability, tissue distribution, and turnover of vitamin B3 in vivo.
• Radiochemical Synthesis: Serves as a labeled building block for the synthesis of more complex carbon-14 labeled molecules for research.
• Environmental Fate Studies: Applied in research to track the environmental degradation and transformation of nicotinamide-related compounds.

Basic Information

Product Name	Nicotinamide, [Carbonyl-14C]
CAS No.	10119-18-3
Molecular Formula	C6H614CON2
Molecular Weight	~123.1 g/mol (exact mass depends on specific activity)
Synonyms	Nicotinamide-carbonyl-14C; Vitamin B3-carbonyl-14C; 3-Pyridinecarboxamide-carbonyl-14C; Niacinamide-carbonyl-14C; [14C]-Nicotinamide; Nicotinic acid amide-carbonyl-14C; Pyridine-3-carboxamide-carbonyl-14C; NSC 13128-carbonyl-14C
EINECS	Contact for details

Quality Control

Every batch of our Nicotinamide, [Carbonyl-14C] is manufactured and analyzed under strict quality systems to ensure high radiochemical purity and specific activity. Quality is verified by advanced analytical techniques including HPLC with radiometric detection. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specific activity, radiochemical purity, chemical purity, and solvent composition. Our production adheres to GLP (Good Laboratory Practice) principles to guarantee data integrity and product consistency for critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature before opening to minimize moisture ingress. For long-term storage, keep the primary container in a secondary sealed vessel with desiccant.

Specification

Item	Specification
Appearance	White to off-white solid or solution
Identification (HPLC, MS)	Conforms to reference standard
Specific Activity	Customizable (e.g., 50-60 mCi/mmol)
Radiochemical Purity (HPLC)	≥ 98%
Chemical Purity (HPLC)	≥ 95%
Solvent	Ethanol, Water, or custom (specified per batch)
Concentration	Customizable (e.g., 1.0 mCi/mL)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.