Description

2-Deaminoactinomycin D is a structural analog of the potent antibiotic and antitumor agent actinomycin D, characterized by the absence of an amino group on the chromophore. This modification is of significant interest in biochemical and pharmacological research for studying structure-activity relationships and developing novel therapeutic agents. It serves as a critical research tool for scientists in oncology, molecular biology, and medicinal chemistry who are investigating DNA intercalation and transcription inhibition mechanisms.

Application

• Biochemical Research: Used as a reference compound to study the mechanism of action of actinomycins and their interaction with DNA.
• Oncology Research: Investigated for its potential antitumor properties and cytotoxicity in various cancer cell line studies.
• Medicinal Chemistry: Serves as a key intermediate or analog in the synthesis and development of new chemotherapeutic agents.
• Molecular Biology: Employed as a tool to inhibit RNA polymerase and study transcriptional regulation in vitro.
• Pharmacology Studies: Used to explore the pharmacokinetics, metabolism, and toxicology profiles of actinomycin derivatives.
• Academic & Institutional Research: A vital reagent for universities and research institutes focusing on antibiotic mechanisms and drug discovery.

Basic Information

Product Name	2-Deaminoactinomycin D
CAS No.	10118-32-8
Molecular Formula	C62H86N12O16
Molecular Weight	1279.44 g/mol
Synonyms	2-Deaminoactinomycin D; 2-Deamino-actinomycin D; Actinomycin D, 2-deamino-; 2-Deamino-Dactinomycin; 7-Aminoactinomycin D analog; NSC 83653
EINECS	Contact for details

Quality Control

Our 2-Deaminoactinomycin D is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the specific results for your quality assurance records.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider keeping the product at -20°C under desiccant.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Biological Activity	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.