Description

The Desmosine Standard is a high-purity reference material essential for the accurate quantification of elastin degradation products. This compound serves as a critical biomarker for research into connective tissue disorders and pulmonary diseases. It is primarily utilized by analytical laboratories, diagnostic manufacturers, and research institutions in the life sciences and pharmaceutical development sectors.

Application

• Biomarker Standard for LC-MS/MS: Used as a primary calibrant for the precise measurement of desmosine and isodesmosine in biological samples like urine and plasma.
• Pulmonary Disease Research: Critical for studies on elastin breakdown in conditions such as chronic obstructive pulmonary disease (COPD), emphysema, and cystic fibrosis.
• Connective Tissue Disorder Analysis: Employed in research on Marfan syndrome, cutis laxa, and other diseases affecting elastic fibers.
• Diagnostic Kit Development: Serves as a key component in the development and validation of immunoassays and chromatographic diagnostic tests.
• Anti-aging and Cosmetic Research: Used to evaluate the efficacy of treatments aimed at preserving or restoring skin elasticity.
• Toxicology Studies: Applied in research investigating lung damage caused by environmental pollutants or smoking.
• Academic and Clinical Research: A fundamental tool for universities and hospitals conducting advanced biochemical and pathological studies.
• Method Validation and Quality Control: Essential for ensuring the accuracy and reproducibility of analytical methods in contract research organizations (CROs).

Basic Information

Product Name	Desmosine Standard
CAS No.	10019-68-8
Molecular Formula	C24H40N5O8
Molecular Weight	526.61 g/mol
Synonyms	Desmosine; L-Desmosine; (2S)-2-Amino-5-[(4S)-4-Amino-4-carboxybutyl]-1-(3-[(2S)-2-Amino-2-carboxyethyl]-3,5-bis(3-aminopropyl)-1H-pyridin-4-yl)pentanoic Acid; 2,2',2'',2'''-(-4-(4-Amino-4-carboxybutyl)-1H-pyridine-3,5-diyl)tetrakis(3-aminopropanoic Acid); Elastin Crosslink; Pyridinium Crosslink Amino Acid
EINECS	Contact for details

Quality Control

Our Desmosine Standard is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via mass spectrometry, to ensure it meets the exacting requirements of analytical reference standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and chromatographic data is provided with every shipment to support your research and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 98.0% (on dried basis)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.