Description

4-(4-Methoxyphenoxy)-3-Nitrobenzotrifluoride is a specialized organic intermediate featuring a benzotrifluoride core substituted with nitro and methoxyphenoxy functional groups. This compound matters for its role as a key building block in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where its unique trifluoromethyl and ether linkages are highly valuable. It is primarily needed by research and development chemists, process scale-up engineers, and manufacturers in the pharmaceutical, agrochemical, and liquid crystal material sectors.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders or requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a key building block for developing new-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group often contributes to improved efficacy and environmental profile.
• Liquid Crystal Materials: Used in the research and production of advanced liquid crystal compounds for displays (LCDs) and optical devices, leveraging its rigid, polarizable molecular structure.
• Organic Electronic Materials: Acts as a component in the development of organic semiconductors, hole-transport materials, or electron-accepting units for OLEDs and photovoltaic cells.
• Dye and Pigment Intermediate: Employed in the synthesis of specialized dyes and pigments, where the nitro and ether groups can be further functionalized to alter color properties and lightfastness.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) for constructing complex biaryl ether systems in medicinal chemistry.
• Academic and Contract Research: Utilized in university and CRO (Contract Research Organization) laboratories for methodological studies and exploring new chemical spaces in synthetic organic chemistry.

Basic Information

Product Name	4-(4-Methoxyphenoxy)-3-Nitrobenzotrifluoride
CAS No.	1996-69-6
Molecular Formula	C14H10F3NO4
Molecular Weight	313.23 g/mol
Synonyms	3-Nitro-4-(4-methoxyphenoxy)benzotrifluoride; 1-Methoxy-4-[4-nitro-3-(trifluoromethyl)phenoxy]benzene; 4-(4-Methoxyphenoxy)-3-nitro-α,α,α-trifluorotoluene; Benzene, 1-methoxy-4-[4-nitro-3-(trifluoromethyl)phenoxy]-; 4-(p-Methoxyphenoxy)-3-nitrobenzotrifluoride; 3-Nitro-4-(p-methoxyphenoxy)benzotrifluoride
EINECS	Contact for details

Quality Control

Our 4-(4-Methoxyphenoxy)-3-Nitrobenzotrifluoride is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality system supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This compound may be light-sensitive; prolonged exposure to light should be avoided. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.