Description

1-Bromo-4-Chloro-2-Fluorobenzene is a high-purity halogenated benzene derivative, a crucial building block in advanced organic synthesis. Its precise substitution pattern makes it an invaluable intermediate for constructing complex molecules where regiochemical control is paramount. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries developing new active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, leveraging the halogen atoms for bioactivity.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals and organic light-emitting diode (OLED) materials.
• Polymer Chemistry: Acts as a monomer or functionalization agent for creating specialty polymers with specific thermal or chemical resistance properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to form biaryl structures.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new synthetic methodologies and creating novel chemical entities.

Basic Information

Product Name	1-Bromo-4-Chloro-2-Fluorobenzene
CAS No.	1996-29-8
Molecular Formula	C6H3BrClF
Molecular Weight	209.44 g/mol
Synonyms	4-Chloro-2-fluoro-1-bromobenzene; 2-Fluoro-4-chloro-1-bromobenzene; 1-Bromo-4-chloro-2-fluorobenzene; 4-Chloro-2-fluorobromobenzene; 2-Fluoro-4-chlorobromobenzene; Benzene, 1-bromo-4-chloro-2-fluoro-; (2-Fluoro-4-chlorophenyl)bromide
EINECS	217-900-5

Quality Control

Our 1-Bromo-4-Chloro-2-Fluorobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurity profile, and physical properties are provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and organic solvents. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.75 g/cm³
Boiling Point	~205-210 °C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.