Description

1-Fluoro-2-(Trifluoromethyl)Thio-Benzene is a high-value fluorinated aromatic building block, distinguished by its unique combination of fluorine and sulfur-containing functional groups. This compound is essential for introducing the (trifluoromethyl)thio group into target molecules, a moiety known to significantly enhance lipophilicity, metabolic stability, and bioavailability. It is critically needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the CF3S- group improves compound penetration and environmental persistence.
• Material Science Precursor: Serves as a building block for specialty polymers, liquid crystals, and electronic materials requiring specific fluorine-thioether functionalities.
• Organic Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to create complex, fluorinated aromatic systems.
• Ligand and Catalyst Development: Useful for modifying ligand structures in catalytic systems to fine-tune electronic properties and steric bulk.

Basic Information

Product Name	1-Fluoro-2-(Trifluoromethyl)Thio-Benzene
CAS No.	1978-16-1
Molecular Formula	C7H4F4S
Molecular Weight	196.17 g/mol
Synonyms	2-Fluoro-α,α,α-trifluorothioanisole; 1-Fluoro-2-[(trifluoromethyl)thio]benzene; o-Fluorophenyl trifluoromethyl sulfide; Benzene, 1-fluoro-2-[(trifluoromethyl)thio]-; 2-Fluorophenyl trifluoromethyl thioether; (2-Fluorophenyl)(trifluoromethyl)sulfide; α,α,α-Trifluoro-2-fluorothioanisole
EINECS	Contact for details

Quality Control

Our production of 1-Fluoro-2-(Trifluoromethyl)Thio-Benzene adheres to stringent internal quality standards to ensure batch-to-batch consistency and reliability for your synthetic processes. Each lot is characterized by advanced analytical techniques including GC, HPLC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.