Description

4-Toluenesulfonyl Bromide is a versatile and highly reactive organosulfur compound, primarily used as a key sulfonylation and brominating agent in organic synthesis. Its value lies in its ability to introduce the tosyl (Ts) protecting group and serve as a precursor for other functionalized sulfonyl derivatives, enabling precise molecular construction. This intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, where it facilitates the development of active ingredients and complex organic molecules.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing sulfonamide moieties or as a protecting group in multi-step synthesis.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides, where the tosyl group can modify biological activity and stability.
• Polymer Chemistry: Acts as an initiator or chain transfer agent in controlled radical polymerization processes and in the synthesis of specialty polymers.
• Organic Synthesis Reagent: Employed as a robust sulfonylation agent for alcohols and amines, and as a source of electrophilic bromine in various substitution reactions.
• Dye and Pigment Manufacturing: Serves as an intermediate in the production of sulfonated dyes and other colorants.
• Chemical Research & Development: A valuable tool in academic and industrial R&D labs for exploring new synthetic methodologies and creating novel chemical entities.

Basic Information

Item	Details
Product Name	4-Toluenesulfonyl Bromide
CAS No.	1950-69-2
Molecular Formula	C7H7BrO2S
Molecular Weight	235.10 g/mol
Synonyms	p-Toluenesulfonyl Bromide; Tosyl Bromide; 4-Methylbenzenesulfonyl Bromide; p-Tosyl Bromide; PTsBr; Bromo(p-tolyl)sulfone; Toluene-4-sulfonyl Bromide; α-Bromo-p-toluenesulfonic Acid
EINECS	217-787-8

Quality Control

Our 4-Toluenesulfonyl Bromide is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. A detailed Certificate of Analysis (COA) documenting identity, purity (typically >98%), and impurity profiles is provided with each shipment to guarantee traceability and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as a strong acid/organic solvent, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	96 - 100 °C
Loss on Drying	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.