Description

α-Toluenesulfonyl Chloride is a versatile and highly reactive organosulfur compound widely used as a key sulfonylation reagent in organic synthesis. Its primary value lies in its ability to introduce the tosyl (Ts) protecting group, a fundamental tool for safeguarding alcohols and amines during complex multi-step reactions. This compound is essential for research chemists and process development scientists across the pharmaceutical, agrochemical, and specialty chemical industries, enabling the synthesis of active pharmaceutical ingredients (APIs), fine chemicals, and advanced materials.

Application

• Pharmaceutical Intermediate Synthesis: A critical reagent for the protection of hydroxyl and amino groups in the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used in the preparation of sulfonamide derivatives and as a protecting group reagent in solid-phase peptide synthesis (SPPS).
• Agrochemical Production: Serves as a building block for creating sulfonamide-based herbicides, fungicides, and other crop protection agents.
• Polymer & Material Science: Employed in the synthesis of specialty polymers, dyes, and photoinitiators where the introduction of sulfonyl groups modifies material properties.
• Organic Synthesis Research: A fundamental tool in academic and industrial R&D labs for constructing complex molecular architectures through selective functional group transformations.
• Chemical Derivatization: Used in analytical chemistry to create derivatives of alcohols and amines for improved detection or separation in chromatographic methods.

Basic Information

Product Name	α-Toluenesulfonyl Chloride
CAS No.	1939-99-7
Molecular Formula	C7H7ClO2S
Molecular Weight	190.65 g/mol
Synonyms	p-Toluenesulfonyl Chloride; Tosyl Chloride; 4-Methylbenzenesulfonyl Chloride; Toluenesulfonyl Chloride; p-Tosyl Chloride; TsCl; Toluene-4-sulfonyl Chloride; 4-Toluenesulfonyl Chloride
EINECS	217-708-2

Quality Control

Our α-Toluenesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch reliability for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed to prevent decomposition from atmospheric moisture. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	67 - 70 °C
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.