Description

5-Hydroxydopamine is a specialized neurotoxic research chemical and synthetic derivative of dopamine. It matters as a critical tool in neuroscience and pharmacological research for selectively destroying catecholaminergic neurons, enabling the study of neurodegenerative processes and Parkinson's disease models. This compound is primarily needed by research institutions, pharmaceutical R&D departments, and chemical suppliers serving the life sciences sector for applications in neurochemistry and experimental neurology.

Application

• Neuroscience Research: Used as a selective neurotoxin to ablate catecholaminergic neurons (dopaminergic and noradrenergic) in experimental models.
• Parkinson's Disease Modeling: Employed to create chemical lesion models of Parkinson's disease in laboratory animals for therapeutic screening.
• Neuropharmacology Studies: Serves as a key agent to investigate neurotransmitter systems, neuronal death pathways, and neuroprotective mechanisms.
• Reference Standard: Acts as a high-purity analytical standard in HPLC, LC-MS, and other chromatographic methods for neurotransmitter analysis.
• Biochemical Reagent: Utilized in enzymatic studies related to catecholamine metabolism and oxidative stress.
• Pharmaceutical Intermediates: May serve as a synthetic precursor or intermediate in the development of novel neuroactive compounds.

Basic Information

Product Name	5-Hydroxydopamine
CAS No.	1927-04-4
Molecular Formula	C8H11NO3
Molecular Weight	169.18 g/mol
Synonyms	6-Hydroxydopamine; 2,4,5-Trihydroxyphenethylamine; 5-OHDA; 6-OHDA; Oxidopamine; 2-(3,4,5-Trihydroxyphenyl)ethylamine; 5-Hydroxy dopamine; 3,4,5-Trihydroxyphenethylamine
EINECS	217-679-8

Quality Control

Our 5-Hydroxydopamine is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing including HPLC for purity, identity confirmation by FT-IR and mass spectrometry, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with our stringent specifications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., argon or nitrogen) at a controlled room temperature (15-25°C) in a dry, cool place. Due to its easily oxidized and light-sensitive nature, prolonged exposure to air, moisture, or light should be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.