Description

2-Nitrobenzenesulfonyl Chloride is a versatile and highly reactive aromatic sulfonyl chloride derivative. This compound serves as a critical building block in organic synthesis, particularly for the introduction of the 2-nitrobenzenesulfonyl (o-Nosyl) protecting group for amines. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require precise and reliable intermediates for complex molecule construction.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of active pharmaceutical ingredients (APIs), especially for amine protection/deprotection strategies.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides where the sulfonyl chloride moiety is incorporated.
• Peptide Chemistry: Acts as an o-Nosyl (Nos) protecting group for amino acids and peptides, offering orthogonal deprotection conditions.
• Dye and Pigment Manufacturing: Intermediate in the synthesis of sulfonated azo dyes and other colorants.
• Polymer Modification: Used to introduce sulfonamide functional groups into polymer chains to alter physical properties.
• Chemical Research & Development: Fundamental reagent in academic and industrial R&D for exploring new synthetic methodologies.

Basic Information

Product Name	2-Nitrobenzenesulfonyl Chloride
CAS No.	1694-92-4
Molecular Formula	C6H4ClNO4S
Molecular Weight	221.62 g/mol
Synonyms	o-Nitrobenzenesulfonyl chloride; 2-Nitrobenzenesulfonyl chloride; Benzenesulfonyl chloride, 2-nitro-; o-Nosyl chloride; 2-Nitrobenzene-1-sulfonyl chloride; NSC 403124; 1-Chlorosulfonyl-2-nitrobenzene
EINECS	216-906-9

Quality Control

Our 2-Nitrobenzenesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic and moisture-sensitive nature, store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong bases, oxidizing agents, and moisture.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	66 - 70 °C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.