Description

1-Bromo-3-Fluoro-4-Trifluoromethoxybenzene is a high-value, multi-functional aromatic building block characterized by its unique combination of bromine, fluorine, and trifluoromethoxy substituents. This compound is essential for introducing specific steric and electronic properties into target molecules, enabling advanced material and pharmaceutical development. It is primarily sought after by R&D chemists and process engineers in the agrochemical, pharmaceutical, and specialty materials industries for constructing complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring fluorinated aromatic cores to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides where the trifluoromethoxy and halogen groups enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals and organic light-emitting diode (OLED) materials, contributing to improved electronic properties and device performance.
• Polymer Modification: Employed to introduce halogenated aromatic units into polymer backbones, altering thermal stability, chemical resistance, and optical properties for high-performance plastics.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) due to the reactive bromine atom, facilitating complex molecular architecture construction.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for exploring new synthetic methodologies and creating novel fluorinated compounds.

Basic Information

Product Name	1-Bromo-3-Fluoro-4-Trifluoromethoxybenzene
CAS No.	1682-06-0
Molecular Formula	C7H3BrF4O
Molecular Weight	258.99 g/mol
Synonyms	4-Bromo-2-fluoro-1-(trifluoromethoxy)benzene; 2-Fluoro-4-bromo-1-(trifluoromethoxy)benzene; 3-Fluoro-4-bromo-α,α,α-trifluoroanisole; Benzene, 1-bromo-3-fluoro-4-(trifluoromethoxy)-; 1-Bromo-3-fluoro-4-(trifluoromethoxy)benzene; 4-Bromo-2-fluoroanisole, α,α,α-trifluoro-
EINECS	Contact for details

Quality Control

Our 1-Bromo-3-Fluoro-4-Trifluoromethoxybenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and organic solvents. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.