Description

n-Acetyl-Glycine-15N is a stable isotope-labeled derivative of the amino acid glycine, where the nitrogen atom is enriched with the 15N isotope. This compound is a critical building block and internal standard for advanced research in metabolomics, proteomics, and pharmaceutical development. It is primarily utilized by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in tracer studies, mass spectrometry, and NMR spectroscopy to elucidate biochemical pathways and drug metabolism.

Application

• Biomedical Research & Tracer Studies: As a 15N-labeled precursor for investigating amino acid metabolism, protein synthesis rates, and nitrogen flux in biological systems.
• Mass Spectrometry (MS) Internal Standard: For the accurate quantification of glycine and its acetylated derivatives in complex biological matrices using LC-MS or GC-MS platforms.
• Nuclear Magnetic Resonance (NMR) Spectroscopy: Serving as a probe in structural biology and metabolic pathway analysis due to the distinct NMR signal of the 15N nucleus.
• Pharmaceutical Development: Used in the research and development of novel therapeutics, particularly in pharmacokinetic (PK) and absorption, distribution, metabolism, and excretion (ADME) studies.
• Diagnostic Reagent Manufacturing: A potential component in the synthesis of labeled compounds for in vitro diagnostic kits and assays.
• Chemical Synthesis Intermediate: For the preparation of more complex 15N-labeled peptides, conjugates, or specialized biochemicals.

Basic Information

Product Name	n-Acetyl-Glycine-15N
CAS No.	1449-79-2
Molecular Formula	C4H715NO3
Molecular Weight	118.10 g/mol (for 15N version)
Synonyms	Aceturic acid-15N; N-Acetylglycine-15N; Glycine, N-acetyl-, 15N-labeled; (Acetylamino)acetic acid-15N; 2-Acetamidoacetic acid-15N; Acetamidoacetic acid-15N; 15N-Acetyl Glycine; N-Acetyl-15N-glycine
EINECS	215-909-4

Quality Control

Our n-Acetyl-Glycine-15N is produced and tested under strict quality management systems. Each batch is characterized to ensure high isotopic enrichment (typically >98 atom % 15N) and chemical purity. Comprehensive analysis includes NMR and MS for isotopic verification and HPLC for chemical purity assessment. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting the specific results for the batch.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccated conditions or under an inert atmosphere to maintain stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to 15N-labeled structure
Purity (HPLC)	≥ 98.0%
15N Isotopic Enrichment (NMR/MS)	≥ 98 atom %
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.