Calcium Channel Blockers
Circulatory System Drugs
- Lipid Regulators
- Antianginals
- Calcium Channel Blockers
- Anticongestive Heart Failure Drugs
- Antihypertensives
- Antiarrhythmics
- Shock Vasoactive Drugs
- Other Cardiovascular Drugs
- ACE Inhibitors and ARBs
- Peripheral Vasodilators
- β-Adrenergic Receptor Blockers
- Chronic Heart Failure Therapeutics
- Antiatherosclerotic Drugs
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Calcium Channel Blockers
Calcium channel blockers (CCBs) inhibit L-type calcium channels in vascular smooth muscle and cardiac tissue, leading to vasodilation, reduced contractility, and decreased cardiac workload. They are categorized into dihydropyridines, which predominantly act on vasculature to lower blood pressure, and non-dihydropyridines (verapamil, diltiazem), which additionally affect cardiac conduction and rate control. CCBs are widely used in hypertension, angina, arrhythmias, and microvascular disease. Their benefits include improved coronary blood flow, reduced afterload, and enhanced exercise tolerance. Adverse effects vary by class and may include edema, headache, bradycardia, or constipation. CCBs remain essential in cardiovascular therapy due to their versatility and strong clinical evidence.
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