Description

(2S,3S,5R)-3-AZIDO-N-(2-((1S,2S,3S,5R,6R)-3,5-DIAZIDO-2-((2S,3R,4R,5S,6R)-3-AZIDO-6-(AZIDOMETHYL)-4,5-DIHYDROXYTETRAHYDRO-2H-PYRAN-2-YLOXY)-6-HYDROXYCYCLOHEXYLAMINO)ETHYL)-5-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)TETRAHYDROFURAN-2-CARBOXAMIDE is a highly complex, multi-functional nucleoside analog derivative designed for advanced pharmaceutical research and development. This compound is engineered as a key synthetic intermediate or potential prodrug candidate, leveraging its unique azide functionalities for bioorthogonal chemistry applications like click chemistry. It is primarily targeted at innovative drug discovery programs in antiviral and anticancer therapeutic areas, where precise molecular architecture is critical for biological activity.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel nucleoside-based antiviral or anticancer agents.
• Click Chemistry Reagent: The multiple azide groups enable efficient, site-specific conjugation with alkyne-bearing molecules for bioconjugation and probe development.
• Prodrug Research: Investigated as a potential prodrug candidate designed for targeted drug delivery and activation.
• Biochemical Tool Compound: Used in mechanistic studies to understand enzyme inhibition, nucleic acid metabolism, and cellular signaling pathways.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize potency and pharmacokinetic properties of lead compounds.
• Academic & Institutional Research: Utilized in cutting-edge chemical biology and drug discovery projects within university and research institute laboratories.

Basic Information

Product Name	(2S,3S,5R)-3-AZIDO-N-(2-((1S,2S,3S,5R,6R)-3,5-DIAZIDO-2-((2S,3R,4R,5S,6R)-3-AZIDO-6-(AZIDOMETHYL)-4,5-DIHYDROXYTETRAHYDRO-2H-PYRAN-2-YLOXY)-6-HYDROXYCYCLOHEXYLAMINO)ETHYL)-5-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)TETRAHYDROFURAN-2-CARBOXAMIDE
CAS No.	948916-05-0
Molecular Formula	C27H38N18O11
Molecular Weight	766.71 g/mol
Synonyms	1-(5-Azido-2,5-dideoxy-β-D-ribofuranosyl)thymine multi-azido derivative; Azido-functionalized nucleoside analog; Thymidine azido derivative; Clickable nucleoside intermediate; CAS 948916-05-0; Multi-azido prodrug candidate; Complex azido nucleoside
EINECS	Contact for details

Quality Control

This high-value synthetic intermediate is produced under strict quality control protocols in a cGMP-compliant environment suitable for research and development use. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and Mass Spectrometry to confirm identity, purity, and structural integrity. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and residual solvents is provided with each shipment to ensure traceability and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. The compound is both light-sensitive and moisture-sensitive; allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. Store away from strong acids, bases, and reducing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.